PO-04-094 RELEVANCE OF MICROBUBBLE FORMATION WITH PULSED FIELD ABLATION SHOWING IRREVERSIBLE ELECTROPORATION IN A CANINE MODEL

With ablation using a saline flow catheter tips, occasionally microbubbles will be seen, either from excessive heating or steam pops. The occurrence and implications of microbubble formation with PFA/IRE has not been determined. This study aim was to clarify the means during ablation. Therefore, total 4 dogs underwent evaluation delivery 34 ablated lesions in right left atrium. During ablation, we monitored by ICE imaging whether occurred. these, were seen 82% deliveries. class I 25 %, II III 50 %. There appeared no untoward effect microbubbles. However, others, suggested biophysical property seen. In those positioning directly perpendicular endocardial surface, less common. On other hand, more parallel tip positioning, lowere contact force, could reach level. These different than past studies showing simple heat related PFA is present. Nevertheless, process electrophoresis create greater extent irrigation catheter’s flow. concern this decrease effectiveness as judged high-density mapping. study, actual perforations but there an energy loss electrophoretic effects. Actually, gross pathology, lesion length width ranged 16.5 24.1 mm 11.9 21.8 RA. Class are readily appear that irrigation-tip catheters. marked suggests process, which like incomplete result substantial rendering effective. Even enough PFA/IRE, substantial. While few complications producing microbubbles, also high output pacing diminution histology.